Ranges from subtle swelling at base of anal column to mass protruding into anal canal May be associated with or thought to be hemorrhoids May be adjacent to inflammation, abscess, tumor Tend to enlarge over time May be asymptomatic or associated with pain, discharge, itching, especially if longstanding If pathology is isolated to hypertrophied papillae, resection is curative; otherwise, underlying pathology must be treated to relieve symptoms Similarly to hemorrhoids, histopathologic evaluation is necessary to exclude accompanying lesions, such as low or high grade squamous intraepithelial lesions, invasive squamous cell carcinoma, rectal carcinoma, neuroendocrine tumors, melanoma, lymphoma, inflammatory bowel disease, nonspecific granulomas, herpes simplex virus infection, syphilis. These may be asymptomatic, but often become complicated by ulceration, faecal retention and constipation. Typical hypertrophied anal papillae. A variant associated with lichen sclerosus may also occur. Home About Us Advertise Amazon.